Table 2.
Comparison of biomarker levels for patients with and without anastomotic leakage (AL).
| AL | Postoperative day 1 | Postoperative day 2 | Postoperative day 3 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | Median | Q1 | Q3 | P‐value | n | Median | Q1 | Q3 | P‐value | n | Median | Q1 | Q3 | P‐value | ||
| MMP2 × 105 (pg/ml) | Y | 37 | 0.7 | 0.5 | 1.2 | 1.000 | 31 | 1.0 | 0.6 | 1.4 | 1.000 | 31 | 1.1 | 0.7 | 2.1 | 1.000 |
| N | 248 | 0.7 | 0.4 | 1.1 | 236 | 1.0 | 0.6 | 1.4 | 230 | 1.2 | 0.7 | 1.7 | ||||
| MMP9 × 105 (pg/ml) | Y | 37 | 3.2 | 0.9 | 10.8 | 0.450 | 31 | 1.7 | 0.4 | 7.0 | 1.000 | 32 | 2.0 | 0.5 | 5.0 | 0.011 |
| N | 247 | 2.0 | 0.9 | 4.1 | 235 | 1.0 | 0.5 | 2.0 | 231 | 0.6 | 0.3 | 1.5 | ||||
| Glucose (mm) | Y | 37 | 2.0 | 0.4 | 3.8 | 0.252 | 38 | 0.2 | 0.1 | 2.4 | < 0.001 | 35 | 0.3 | 0.1 | 3.1 | 0.011 |
| N | 247 | 3.4 | 1.5 | 4.6 | 241 | 2.4 | 0.1 | 4.7 | 238 | 2.9 | 0.1 | 5.0 | ||||
| Lactate (mm) | Y | 37 | 10.5 | 6.9 | 14.5 | 1.000 | 38 | 12.5 | 9.1 | 19.7 | 1.000 | 37 | 11.3 | 8.1 | 19.2 | 0.444 |
| N | 248 | 9.1 | 6.2 | 13.2 | 242 | 11.1 | 6.4 | 17.3 | 243 | 9.2 | 5.2 | 14.9 | ||||
| CRP (mg/ml) | Y | 36 | 69.5 | 35.0 | 105.8 | 0.459 | 36 | 152.5 | 83.5 | 215.5 | < 0.001 | 37 | 170.0 | 113.8 | 290.5 | < 0.001 |
| N | 241 | 50.0 | 30.9 | 80.0 | 213 | 86.0 | 47.1 | 135.9 | 215 | 78.0 | 41.0 | 125.0 | ||||
| IL1β (pg/ml) | Y | 37 | 61.1 | 31.7 | 263.5 | 0.341 | 32 | 138.1 | 46.7 | 536.8 | 0.011 | 31 | 190.0 | 28.6 | 3271.1 | < 0.001 |
| N | 247 | 47.1 | 19.6 | 132.3 | 236 | 39.8 | 13.4 | 151.5 | 232 | 30.3 | 9.3 | 142.9 | ||||
| IL6 (pg/ml) | Y | 36 | 69717.7 | 19267.2 | 76184.2 | 1.000 | 32 | 73454.5 | 23889.4 | 76334.1 | 1.000 | 31 | 46178.8 | 17483.5 | 76070.8 | 0.301 |
| N | 246 | 51635.3 | 23484.4 | 76070.8 | 236 | 41860.7 | 17483.5 | 75786.4 | 232 | 24738.2 | 11239.9 | 68858.8 | ||||
| IL10 (pg/ml) | Y | 37 | 249.7 | 141.3 | 594.6 | 0.584 | 32 | 176.3 | 84.4 | 630.8 | 0.080 | 31 | 128.3 | 38.6 | 554.2 | 0.072 |
| N | 247 | 204.8 | 109.7 | 405.5 | 236 | 99.1 | 51.8 | 220.8 | 232 | 62.4 | 30.0 | 136.4 | ||||
| TNFα (pg/ml) | Y | 37 | 37.3 | 23.6 | 128.8 | 0.156 | 32 | 23.1 | 12.9 | 67.2 | 1.000 | 31 | 45.2 | 14.2 | 79.7 | 0.036 |
| N | 246 | 30.1 | 16.4 | 59.1 | 237 | 21.5 | 12.0 | 39.8 | 231 | 17.7 | 9.9 | 34.0 | ||||
| Escherichia coli (Ct) | Y | 37 | 34.2 | 32.4 | 35.8 | 1.000 | 33 | 34.8 | 31.4 | 37.5 | 1.000 | 30 | 34.3 | 26.7 | 36.4 | 1.000 |
| N | 247 | 34.6 | 32.4 | 37.0 | 231 | 34.6 | 32.4 | 36.7 | 227 | 34.7 | 32.9 | 36.6 | ||||
| Enterococcus faecalis (Ct) | Y | 38 | 26.3 | 25.2 | 26.9 | 1.000 | 33 | 26.5 | 25.4 | 27.5 | 1.000 | 32 | 26.2 | 25.1 | 27.4 | 1.000 |
| N | 248 | 26.2 | 25.1 | 27.1 | 234 | 26.0 | 25.0 | 27.0 | 228 | 25.9 | 25.1 | 27.0 | ||||
| LBP (μg/ml) | Y | 38 | 3.6 | 1.9 | 5.0 | 1.000 | 34 | 5.5 | 3.5 | 6.6 | 1.000 | 31 | 6.2 | 4.6 | 7.0 | 1.000 |
| N | 248 | 3.2 | 2.2 | 4.4 | 237 | 5.1 | 4.0 | 6.1 | 231 | 5.6 | 4.5 | 6.7 | ||||
| Amylase (U/l) | Y | 36 | 36.0 | 14.3 | 84.8 | 0.584 | 38 | 30.5 | 13.5 | 47.0 | 1.000 | 37 | 24.0 | 17.5 | 45.0 | 1.000 |
| N | 243 | 24.0 | 13.0 | 41.0 | 243 | 28.0 | 18.0 | 45.0 | 244 | 25.0 | 15.0 | 37.0 | ||||
Bold values indicate significance.
CRP, C‐reactive protein; IL, interleukin; LBP, lipopolysaccharide‐binding protein; MMP, matrix metalloproteinase; n, number of patients; Q1, first quartile; Q3, third quartile; TNFα, tumour necrosis factor alpha.