Table 3.

Outcomes of multivariate penalized logistic regression for anastomotic leakage (AL) per postoperative day.

	Postoperative day 1				Postoperative day 2				Postoperative day 3
	OR	95% CI (lower)	95% CI (upper)	P‐value	OR	95% CI (lower)	95% CI (upper)	P‐value	OR	95% CI (lower)	95% CI (upper)	P‐value
MMP2 (pg/ml)	1.011	0.962	1.063	0.661	1.020	0.955	1.090	0.556	1.025	0.986	1.066	0.216
MMP9 (pg/ml)	1.106	0.995	1.229	0.063*	1.094	0.952	1.257	0.203	1.130	0.982	1.301	0.088‡
Glucose (mm)	0.939	0.751	1.176	0.585	0.916	0.728	1.152	0.453	0.920	0.734	1.152	0.466
Lactate (mm)	0.990	0.890	1.101	0.854	0.993	0.912	1.081	0.869	0.987	0.917	1.063	0.737
CRP (mg/ml)	1.068	0.981	1.162	0.128	1.057	1.005	1.111	0.030†	1.064	1.013	1.118	0.013‡
IL1β (pg/ml)	1.002	0.992	1.012	0.702	0.999	0.992	1.006	0.787	1.001	0.999	1.003	0.522
IL6 (pg/ml)	0.980	0.847	1.135	0.787	1.052	0.899	1.230	0.529	0.939	0.788	1.119	0.481
IL10 (pg/ml)	0.999	0.980	1.019	0.954	1.044	0.940	1.159	0.424	1.110	0.959	1.284	0.161
TNFα (pg/ml)	1.037	0.998	1.077	0.062*	0.991	0.969	1.014	0.453	1.011	0.996	1.026	0.136
Escherichia coli (Ct)	0.975	0.852	1.115	0.707	0.947	0.830	1.081	0.422	1.029	0.905	1.169	0.664
Enterococcus faecalis (Ct)	1.072	0.756	1.520	0.697	1.179	0.820	1.695	0.373	1.009	0.703	1.448	0.960
LBP (μg/ml)	0.913	0.704	1.184	0.492	0.910	0.708	1.170	0.462	0.888	0.686	1.149	0.365
Amylase (U/l)	1.000	0.998	1.003	0.827	1.001	0.998	1.003	0.648	1.000	0.999	1.001	0.547
Age	0.978	0.944	1.013	0.222	0.973	0.936	1.010	0.154	0.986	0.948	1.027	0.503
Gender	0.931	0.415	2.088	0.862	0.866	0.367	2.044	0.743	0.698	0.275	1.772	0.449
NSAIDs	0.719	0.131	3.953	0.704	0.454	0.051	4.042	0.479	1.018	0.172	6.028	0.985
Corticosteroids	1.066	0.263	4.315	0.928	1.132	0.252	5.093	0.871	1.087	0.267	4.430	0.908
Diverting ileostomy	0.478	0.205	1.116	0.088*	0.485	0.195	1.208	0.120	0.575	0.219	1.511	0.261
Procedure	2.829	0.888	9.014	0.079*	2.540	0.787	8.193	0.119	2.229	0.603	8.239	0.229
Surgical technique	0.756	0.151	3.787	0.733	0.804	0.152	4.252	0.797	1.047	0.197	5.557	0.957

CI, confidence interval; CRP, C‐reactive protein; IL, interleukin; LBP, lipopolysaccharide‐binding protein; MMP, matrix metalloproteinase; NSAID, nonsteroidal anti‐inflammatory drug; OR, odds ratio.

*These variables were added to the prediction model of postoperative day 1.

†These variables were added to the prediction model of postoperative day 2.

‡These variables were added to the prediction model of postoperative day 3.