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. 2020 Jan 14;10:3064. doi: 10.3389/fimmu.2019.03064

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Copyright © 2020 Degroote, Weigand, Hauck and Deeg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Network clustering for biological processes to which differentially expressed proteins from IL8 (A) and PMA (B) stimulation were appointed. Three distinct clusters are visible in each stimulation group. Two clusters show similarities between stimulants (dotted blue arrow: granulocyte activation and metabolic processes) whereas one cluster is unique for each group [red arrow: immune response signaling pathways in IL8 stimulated cells (A) and cellular protein localization in PMA stimulated cells (B)]. For a more clear presentation of clusters, we searched 20 most significant categories instead of 30.