Table 2.
Enrichment of functional categories describing biological proccesses generated from proteins with differential expression after IL8 and PMA stimulation.
| Enrichment FDR | Genes in list | Total genes | Functional category | Genes |
|---|---|---|---|---|
| Biological proccesses from unique Proteins with ratio IL8/mc ≥ 2 | ||||
| 0.0033 | 4 | 133 | Fc-epsilon receptor signaling pathway | PSMC6 IKBKB VAV2 PSMD12 |
| 0.0062 | 10 | 2,602 | Immune response | PAG1 CDC37 CASP1 ADAMDEC1 PSMC6 IKBKB CREG1 VAV2 PSMD12 DDOST |
| 0.0062 | 4 | 210 | Tumor necrosis factor-mediated signaling pathway | IKBKB CASP1 PSMC6 PSMD12 |
| 0.0062 | 4 | 203 | Fc receptor signaling pathway | PSMC6 IKBKB VAV2 PSMD12 |
| 0.0062 | 5 | 466 | Immune response-activating cell surface receptor signaling pathway | PAG1 PSMC6 IKBKB VAV2 PSMD12 |
| 0.0081 | 4 | 275 | T cell receptor signaling pathway | PAG1 PSMC6 IKBKB PSMD12 |
| 0.0081 | 5 | 520 | Immune response-regulating cell surface receptor signaling pathway | PAG1 PSMC6 IKBKB VAV2 PSMD12 |
| 0.0091 | 6 | 1,050 | Regulation of catabolic process | CARHSP1 SH3GLB1 PSMC6 CDC37 AIFM1 PSMD12 |
| 0.0091 | 5 | 662 | Posttranscriptional regulation of gene expression | CARHSP1 CDC37 SARNP PSMC6 PSMD12 |
| 0.0091 | 6 | 928 | Regulation of cellular catabolic process | CARHSP1 SH3GLB1 PSMC6 CDC37 AIFM1 PSMD12 |
| 0.0091 | 3 | 141 | Innate immune response activating cell surface receptor signaling pathway | PSMC6 IKBKB PSMD12 |
| 0.0091 | 3 | 135 | Stimulatory C-type lectin receptor signaling pathway | PSMC6 IKBKB PSMD12 |
| 0.0091 | 4 | 368 | Response to tumor necrosis factor | IKBKB CASP1 PSMC6 PSMD12 |
| 0.0091 | 3 | 147 | Antigen processing and presentation of exogenous peptide antigen via MHC class I | PSMC6 IKBKB PSMD12 |
| 0.0091 | 3 | 143 | Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | PSMC6 IKBKB PSMD12 |
| 0.0091 | 4 | 323 | Antigen receptor-mediated signaling pathway | PAG1 PSMC6 IKBKB PSMD12 |
| 0.0091 | 5 | 662 | Immune response-activating signal transduction | PAG1 PSMC6 IKBKB VAV2 PSMD12 |
| 0.0091 | 3 | 118 | Interleukin-1-mediated signaling pathway | IKBKB PSMC6 PSMD12 |
| 0.0091 | 4 | 344 | Cellular response to tumor necrosis factor | IKBKB CASP1 PSMC6 PSMD12 |
| 0.0102 | 5 | 712 | Nucleobase-containing compound catabolic process | CARHSP1 AIFM1 CNP PSMC6 PSMD12 |
| 0.0102 | 2 | 34 | Positive regulation of phosphatidylinositol 3-kinase activity | SH3GLB1 VAV2 |
| 0.0102 | 5 | 714 | Immune response-regulating signaling pathway | PAG1 PSMC6 IKBKB VAV2 PSMD12 |
| 0.0104 | 3 | 167 | Antigen processing and presentation of peptide antigen via MHC class I | PSMC6 IKBKB PSMD12 |
| 0.0110 | 2 | 38 | Positive regulation of lipid kinase activity | SH3GLB1 VAV2 |
| 0.0110 | 3 | 182 | Regulation of cytokine-mediated signaling pathway | CDC37 CASP1 IKBKB |
| 0.0110 | 5 | 763 | Activation of immune response | PAG1 PSMC6 IKBKB VAV2 PSMD12 |
| 0.0110 | 5 | 765 | Cellular nitrogen compound catabolic process | CARHSP1 AIFM1 CNP PSMC6 PSMD12 |
| 0.0110 | 5 | 764 | Heterocycle catabolic process | CARHSP1 AIFM1 CNP PSMC6 PSMD12 |
| 0.0114 | 5 | 778 | Aromatic compound catabolic process | CARHSP1 AIFM1 CNP PSMC6 PSMD12 |
| 0.0122 | 5 | 813 | Organic cyclic compound catabolic process | CARHSP1 AIFM1 CNP PSMC6 PSMD12 |
| Biological proccesses from unique proteins with ratio PMA/mc ≥ 2 | ||||
| 4.15E-05 | 42 | 2,220 | Vesicle-mediated transport | BCAP29 CHMP3 VPS26A HIST1H1A SYT5 SNX27 VTI1A VPS11 VPS28 TMED10 RAB43 SEC24A ATP6AP1 DNM1L DENND3 ESYT2 NUMB BIN1 SYTL3 MCFD2 MYO1E CD300LF TAPBP GRN PKP1 HUWE1 PGRMC1 PSMD7 QSOX1 HVCN1 ATP8A1 UBR4 GMFG DCTN3 ADAM10 S100A7 CD109 FABP5 GHDC AGPAT2 A2M GM2A |
| 5.76E-05 | 22 | 778 | Aromatic compound catabolic process | COMT RBM8A NUDT3 ISG20 NT5C1A RNASEL ADPGK BPGM PKP1 NAF1 SERBP1 RPL18 PSMA7 PSMD7 NUP210 RPS8 RPL9 RPL15 RPL12 PSMB8 NUP62 PSMB9 |
| 5.76E-05 | 21 | 712 | Nucleobase-containing compound catabolic process | RBM8A NUDT3 ISG20 NT5C1A RNASEL ADPGK BPGM PKP1 NAF1 SERBP1 RPL18 PSMA7 PSMD7 NUP210 RPS8 RPL9 RPL15 RPL12 PSMB8 NUP62 PSMB9 |
| 5.76E-05 | 25 | 951 | Viral process | OAS3 CHMP3 RNASEL KARS PSMA7 EIF4H IRF3 UBR4 BIN1 COPS6 ISG15 PSMB8 NUP62 PSMB9 NUCKS1 ISG20 RAB43 PI4KA RPL18 NUP210 RPS8 VPS28 RPL9 RPL15 RPL12 |
| 8.17E-05 | 22 | 813 | Organic cyclic compound catabolic process | COMT RBM8A NUDT3 ISG20 NT5C1A RNASEL ADPGK BPGM PKP1 NAF1 SERBP1 RPL18 PSMA7 PSMD7 NUP210 RPS8 RPL9 RPL15 RPL12 PSMB8 NUP62 PSMB9 |
| 8.17E-05 | 25 | 1,024 | Symbiont process | OAS3 CHMP3 RNASEL KARS PSMA7 EIF4H IRF3 UBR4 BIN1 COPS6 ISG15 PSMB8 NUP62 PSMB9 NUCKS1 ISG20 RAB43 PI4KA RPL18 NUP210 RPS8 VPS28 RPL9 RPL15 RPL12 |
| 9.22E-05 | 21 | 765 | Cellular nitrogen compound catabolic process | RBM8A NUDT3 ISG20 NT5C1A RNASEL ADPGK BPGM PKP1 NAF1 SERBP1 RPL18 PSMA7 PSMD7 NUP210 RPS8 RPL9 RPL15 RPL12 PSMB8 NUP62 PSMB9 |
| 9.22E-05 | 21 | 764 | Heterocycle catabolic process | RBM8A NUDT3 ISG20 NT5C1A RNASEL ADPGK BPGM PKP1 NAF1 SERBP1 RPL18 PSMA7 PSMD7 NUP210 RPS8 RPL9 RPL15 RPL12 PSMB8 NUP62 PSMB9 |
| 0.0001 | 36 | 1,981 | Cellular protein localization | HUWE1 VPS11 BCAP29 TBC1D13 SPCS2 VPS26A TM9SF2 UQCRC2 SNX27 VTI1A VPS28 TMED10 ARL6IP1 RAB43 NUP62 SYNE2 SYNE1 DNM1L RIPOR2 SEC24A ADAM10 SYTL3 PPM1F MTCH2 NUMB EPB41 MYADM RPL18 SRSF6 SSR1 NUP210 RPS8 RPL9 RPL15 RPL12 RBM8A |
| 0.0001 | 48 | 3,087 | Cellular localization | HUWE1 VPS11 BCAP29 DNM1L TBC1D13 COL4A3BP CHMP3 SPCS2 VPS26A TM9SF2 SYT5 UQCRC2 SNX27 VTI1A VPS28 TMED10 ARL6IP1 RAB43 NUP62 SYNE2 SEC24A SYNE1 TRPC3 BAK1 ATP6AP1 DENND3 RIPOR2 ESYT2 NUMB BIN1 ADAM10 SYTL3 PPM1F MTCH2 CPSF6 EPB41 MYADM RPL18 SRSF6 SSR1 NUP210 DCTN3 RPS8 RPL9 RPL15 MCFD2 RPL12 RBM8A |
| 0.0001 | 25 | 1,084 | Interspecies interaction between organisms | OAS3 CHMP3 RNASEL KARS PSMA7 EIF4H IRF3 UBR4 BIN1 COPS6 ISG15 PSMB8 NUP62 PSMB9 NUCKS1 ISG20 RAB43 PI4KA RPL18 NUP210 RPS8 VPS28 RPL9 RPL15 RPL12 |
| 0.0001 | 36 | 1,993 | Cellular macromolecule localization | HUWE1 VPS11 BCAP29 TBC1D13 SPCS2 VPS26A TM9SF2 UQCRC2 SNX27 VTI1A VPS28 TMED10 ARL6IP1 RAB43 NUP62 SYNE2 SYNE1 DNM1L RIPOR2 SEC24A ADAM10 SYTL3 PPM1F MTCH2 NUMB EPB41 MYADM RPL18 SRSF6 SSR1 NUP210 RPS8 RPL9 RPL15 RPL12 RBM8A |
| 0.0001 | 24 | 1,023 | Exocytosis | SYT5 VPS11 ATP6AP1 DNM1L SYTL3 TMED10 GRN PKP1 HUWE1 PGRMC1 PSMD7 QSOX1 HVCN1 ATP8A1 UBR4 GMFG ADAM10 S100A7 CD109 FABP5 GHDC AGPAT2 A2M GM2A |
| 0.0002 | 35 | 1,959 | Intracellular transport | HUWE1 VPS11 BCAP29 TBC1D13 COL4A3BP CHMP3 SPCS2 VPS26A SYT5 UQCRC2 SNX27 VTI1A VPS28 TMED10 ARL6IP1 RAB43 NUP62 SEC24A SYNE2 DNM1L DENND3 SYTL3 CPSF6 BIN1 RPL18 SRSF6 SSR1 NUP210 DCTN3 RPS8 RPL9 RPL15 MCFD2 RPL12 RBM8A |
| 0.0002 | 41 | 2,500 | Cellular catabolic process | HUWE1 DNM1L COMT PSMA7 PSMD7 UBR4 ECHS1 VPS28 CYP2C19 PSMB8 HBE1 PSMB9 RBM8A NUDT3 CAMKK2 ISG20 RENBP DENND3 NT5C1A USP15 RNASEL ADPGK VPS11 BPGM ISG15 GM2A PKP1 QSOX1 NAF1 VTI1A SERBP1 RPL18 CHMP3 VPS26A NUP210 RPS8 RPL9 FABP5 RPL15 RPL12 NUP62 |
| 0.0003 | 46 | 3,011 | Organic substance transport | HUWE1 VPS11 TBC1D13 COL4A3BP CHMP3 SPCS2 VPS26A ATP8A1 SLC17A3 SYT5 UQCRC2 SNX27 VTI1A SLC28A1 VPS28 TMED10 ARL6IP1 RAB43 NUP62 KARS DNM1L RHAG ACSL4 BCAP29 SEC24A ESYT2 IRF3 NUP210 RNASEL SYTL3 FABP5 MCFD2 GM2A RBM8A PPM1F CPSF6 MCU RPL18 ATP6AP1 VDAC3 SRSF6 SSR1 RPS8 RPL9 RPL15 RPL12 |
| 0.0003 | 15 | 465 | RNA catabolic process | RBM8A ISG20 RNASEL PKP1 NAF1 SERBP1 RPL18 PSMA7 PSMD7 RPS8 RPL9 RPL15 RPL12 PSMB8 PSMB9 |
| 0.0003 | 49 | 3,354 | Macromolecule localization | HUWE1 NAF1 VPS11 BCAP29 TBC1D13 COL4A3BP CHMP3 SPCS2 VPS26A ATP8A1 TM9SF2 UQCRC2 SNX27 VTI1A VPS28 TMED10 ARL6IP1 RAB43 NUP62 SYNE2 KARS DNM1L SYNE1 ACSL4 RIPOR2 SEC24A ESYT2 IRF3 NUP210 ADAM10 SYTL3 MCFD2 GM2A RBM8A PPM1F MTCH2 CPSF6 NUMB MCU EPB41 MYADM RPL18 ATP6AP1 SRSF6 SSR1 RPS8 RPL9 RPL15 RPL12 |
| 0.0004 | 41 | 2,592 | Nitrogen compound transport | HUWE1 VPS11 TBC1D13 RHAG COL4A3BP CHMP3 SPCS2 VPS26A SLC17A3 SYT5 UQCRC2 SNX27 VTI1A SLC28A1 VPS28 TMED10 ARL6IP1 RAB43 NUP62 KARS DNM1L BCAP29 TAPBP SEC24A IRF3 NUP210 SYTL3 MCFD2 RBM8A PPM1F CPSF6 MCU RPL18 ATP6AP1 VDAC3 SRSF6 SSR1 RPS8 RPL9 RPL15 RPL12 |
| 0.0004 | 17 | 603 | Granulocyte activation | KARS GRN PKP1 HUWE1 PGRMC1 PSMD7 QSOX1 HVCN1 ATP8A1 UBR4 GMFG ADAM10 S100A7 FABP5 GHDC AGPAT2 GM2A |
| 0.0004 | 25 | 1,194 | Intracellular protein transport | HUWE1 VPS11 TBC1D13 SPCS2 VPS26A UQCRC2 SNX27 VTI1A VPS28 TMED10 ARL6IP1 RAB43 NUP62 BCAP29 SEC24A SYTL3 RPL18 SRSF6 SSR1 NUP210 RPS8 RPL9 RPL15 RPL12 RBM8A |
| 0.0004 | 26 | 1,276 | Organic acid metabolic process | SARS KARS VARS HARS2 ECHS1 YARS ENOPH1 CYP2C19 GRHPR CES2 ACSL4 COMT RENBP HSD17B12 ADPGK FABP5 BPGM SLC17A3 PSMA7 PSMD7 ABHD14B NUP210 B3GNT2 PSMB8 NUP62 PSMB9 |
| 0.0004 | 21 | 901 | Regulated exocytosis | SYT5 DNM1L TMED10 GRN PKP1 HUWE1 PGRMC1 PSMD7 QSOX1 HVCN1 ATP8A1 UBR4 GMFG ADAM10 S100A7 CD109 FABP5 GHDC AGPAT2 A2M GM2A |
| 0.0004 | 43 | 2,825 | Catabolic process | HUWE1 DNM1L COMT PSMA7 PSMD7 UBR4 ECHS1 VPS28 CYP2C19 PSMB8 HBE1 PSMB9 RBM8A NUDT3 CAMKK2 ISG20 IRAK3 RENBP DENND3 NT5C1A USP15 RNASEL ADPGK VPS11 BPGM ISG15 GM2A PKP1 QSOX1 NAF1 VTI1A SERBP1 RPL18 CHMP3 VPS26A NUP210 RPS8 RPL9 FABP5 CES2 RPL15 RPL12 NUP62 |
| 0.0005 | 38 | 2,364 | Establishment of localization in cell | HUWE1 VPS11 BCAP29 TBC1D13 COL4A3BP CHMP3 SPCS2 VPS26A SYT5 UQCRC2 SNX27 VTI1A VPS28 TMED10 ARL6IP1 RAB43 NUP62 SEC24A TRPC3 BAK1 SYNE2 DNM1L DENND3 NUMB SYTL3 CPSF6 BIN1 RPL18 SRSF6 SSR1 NUP210 DCTN3 RPS8 RPL9 RPL15 MCFD2 RPL12 RBM8A |
| 0.0006 | 16 | 577 | Neutrophil degranulation | GRN PKP1 HUWE1 PGRMC1 PSMD7 QSOX1 HVCN1 ATP8A1 UBR4 GMFG ADAM10 S100A7 FABP5 GHDC AGPAT2 GM2A |
| 0.0006 | 17 | 640 | Myeloid cell activation involved in immune response | KARS GRN PKP1 HUWE1 PGRMC1 PSMD7 QSOX1 HVCN1 ATP8A1 UBR4 GMFG ADAM10 S100A7 FABP5 GHDC AGPAT2 GM2A |
| 0.0006 | 16 | 576 | Positive regulation of locomotion | SEMA3E KARS S100A7 CARMIL2 SYNE2 RIPOR2 ATP8A1 PPM1F CHMP3 NUMB GRN CASS4 PFN1 SOD2 ADAM10 MYADM |
| 0.0006 | 55 | 4,098 | Organelle organization | RBBP4 HUWE1 VPS11 RECQL TACC3 SYNE2 ARHGAP10 ADD2 PKP1 DNM1L CASS4 DOT1L H2AFV PFN1 HIST1H1A GMFG UQCRC2 ADD3 VTI1A EPB41 TMED10 WDR5 RPL12 CAMKK2 BAK1 GRN PPM1F SEC24A SYNE1 USP15 SERBP1 CARMIL2 ARL6IP1 HIST1H3A NUCKS1 RPS6KA2 VDAC3 RBBP7 COL4A3BP BIN1 SEMA3E CHMP3 IMMT NAF1 RAB43 DES MYADM NUP62 SOD2 ZSCAN4 TAPBP DCTN3 VPS28 COPS6 MCFD2 |
| 0.0006 | 25 | 1,253 | Cellular protein-containing complex assembly | ADD2 DNM1L EIF4H PFN1 SRSF6 GMFG NAF1 ADD3 VPS11 PRPF8 RPL12 SF3A1 CPSF6 SEC24A CHMP3 CARMIL2 RBBP4 HIST1H3A HIST1H1A BIN1 EIF3H TAPBP MYADM RBBP7 TMED10 |
Proteins used were uniquely expressed in each stimulation group.