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. 2019 Oct 6;61(1):152–175. doi: 10.1002/em.22326

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Published 2019. This article is a U.S. Government work and is in the public domain in the USA. Environmental and Molecular Mutagenesis published by Wiley Periodicals, Inc. on behalf of Environmental Mutagen Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Prevalence of hotspot codon targets within the top 20 most mutated CD genes, analyzed by cancer type. The numbers of mutants occurring at specific codons within cancers reported in the COSMIC database were analyzed (different mutations occurring at the same codon were combined). Some of the most mutated CD genes did not contain hotspots for mutation. The percentages of the 20 most mutated genes for which hotspot codons were identified is depicted in (A), for the different cancer types. The total numbers of hotspot codons in the top 20 most highly mutated genes for each cancer type are shown in (B). The fractions of total tumors represented by identified hotspot codons are shown in (C). The factions of mutated tumors represented by identified hotspot codons are shown in (D), with MFs color coded by tumor type, using the color coding identified as in (C).