Table 3.
Genes with hCDMs and Functions Related to Cell Communication
| Gene ID | Cell communication function | Signaling pathway participation | References |
|---|---|---|---|
| AKT1 | Autocrine; juxtacrine; paracrine; endocrine | PI3 kinase signaling pathway | Seo et al. 2016, Armstrong and Drummond‐Barbosa 2018, Ju et al. 2007, Singh et al. 2016 |
| APC | Autocrine; juxtacrine; paracrine; endocrine | Wnt–β‐catenin signaling pathway | Zhu et al. 2014, Ølstørn et al. 2003, Buller et al. 2015, Schinner et al. 2009 |
| AR | Autocrine; juxtacrine; paracrine; endocrine | Androgen receptor signaling pathway | Ware et al. 2014, Lydka et al. 2011, Takuwa et al. 2018, Tanner et al. 2011 |
| ATM | Juxtacrine; paracrine; endocrine | PI3 kinase signaling pathway | Lang et al. 2018, Chen et al. 2015, Karayazi Atici et al. 2017 |
| B2M | Autocrine | Class I MHC mediated antigen processing and presentation pathway | |
| BCL2 | Autocrine | NF‐kappa B signaling pathway; HIF‐1 signaling pathway; sphingolipid signaling pathway; p53 signaling pathway; PI3K‐Akt signaling pathway; Hedgehog signaling pathway; JAK–STAT signaling pathway; estrogen signaling pathway; parathyroid hormone synthesis, secretion, and action | Bold et al. 2001 |
| BRAF | Autocrine; endocrine | MAPK signaling pathway | Huntington et al. 2004,Chernaya et al. 2018 |
| BTG1 | Cell cycle pathway | ||
| CD79B | B‐cell receptor signaling pathway | ||
| CREBBP | cAMP signaling pathway | ||
| CTNNB1 | Juxtacrine; paracrine; endocrine | Wnt signaling pathway; Hippo signaling pathway; Rap1 signaling pathway | Bai et al. 2013, Boyer et al. 2012, Youngblood et al. 2018 |
| DNM2 | Phospholipase D signaling pathway; Toll‐like receptor pathway; neurotrophic receptor Sauer et al. 2017 signaling pathway | ||
| DNMT3A | Chromatin organization pathway | ||
| EGFR | Autocrine; juxtacrine; paracrine; endocrine | MAPK signaling pathway; PI3K‐Akt signaling pathway; JAK–STAT signaling pathway | Chen et al. 2018, Dubé et al. 2012, Zhang et al. 2017, Sauer et al. 2017 |
| ERBB2 | Autocrine; juxtacrine; paracrine; endocrine | ErbB signaling pathway | Li et al. 2004, Hofer et al. 1996, Kim et al. 2011, Chowdhury et al. 2017 |
| ESR1 | Autocrine; endocrine | Estrogen receptor mediated signaling pathway | |
| EZH2 | Autocrine; paracrine; endocrine | Oxidative stress induced senescence pathway | Hartman et al. 2013, Dudakovic et al. 2016, Mathieu et al. 2018 |
| FBXW7 | Endocrine | Notch signaling pathway | Sancho et al. 2014, Mathieu et al. 2018 |
| FLT3 | Autocrine; paracrine | MAPK signaling pathway; Ras signaling pathway; PI3K‐Akt signaling pathway | Zheng et al. 2004, Markovic et al. 2012 |
| GNAS | Endocrine | cAMP signaling pathway | Jin et al. 2019 |
| IDH1 | Paracrine | Citrate cycle TCA cycle pathway | Mao and Leonardi 2019 |
| IDH2 | Paracrine | Citrate Cycle TCA cycle Pathway | Mao and Leonardi 2019 |
| KIT | Autocrine; paracrine | MAPK signaling pathway; Ras signaling pathway; Rap1 signaling pathway; PI3K‐Akt signaling pathway; phospholipase D signaling pathway | Li et al. 2018a, Kim et al. 2018 |
| KRAS | Autocrine; juxtacrine; paracrine; endocrine | MAPK signaling pathway; Ras signaling pathway; PI3K‐Akt signaling pathway; ErbB signaling pathway | Zhu et al. 2014, McKenzie et al. 2016, Liu et al. 2016, Chamberlain et al. 2014 |
| MAP2K2 | Endocrine | MAPK signaling pathway; Ras signaling pathway; PI3K‐Akt signaling pathway; cAMP signaling pathway | Kim et al. 2018 |
| MYD88 | Autocrine; paracrine; endocrine | MAPK signaling pathway; NFκβ signaling pathway | Cataisson et al. 2012, Perkins et al. 2018, Guo et al. 2016 |
| NRAS | Endocrine | MAPK signaling pathway; Ras signaling pathway; ErbB signaling pathway; PI3K‐Akt signaling pathway; mTOR signaling pathway | Argyropoulou et al. 2018 |
| PBRM1 | MAPK signaling pathway | ||
| PIK3CA | Autocrine; paracrine; endocrine | ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; HIF‐1 signaling pathway; FoxO signaling pathway; mTOR signaling pathway; PI3K‐Akt signaling pathway; AMPK signaling pathway; apoptosis signaling pathway; VEGF signaling pathway; JAK–STAT signaling pathway; T‐cell receptor signaling pathway; TNF signaling pathway | Thakur and Ray 2017, Young et al. 2015, Stratikopoulos et al. 2019 |
| RBM10 | Autocrine | Notch signaling pathway | |
| RET | Autocrine; juxtacrine; paracrine; endocrine | RET signaling pathway | Li et al. 2009a, Mazzaferri et al. 1996, Shabtay‐Orbach et al. 2015, Horibata et al. 2018 |
| RHOA | Autocrine; juxtacrine; paracrine; endocrine | Ras signaling pathway; cAMP signaling pathway; mTOR signaling pathway; Wnt signaling pathway | Zhao et al. 2014, Hendrick and Olayioye 2019, Daubriac et al. 2018, Petersen et al. 2018 |
| SMAD4 | Autocrine; juxtacrine; paracrine; endocrine | TGF‐β signaling pathway | Shiou et al. 2006, Wang et al. 2019, Jiang et al. 2015, Li et al. 2018b |
| SOCS1 | Autocrine; paracrine; endocrine | JAK–STAT signaling pathway; Insulin signaling pathway; Prolactin signaling pathway | Niwa et al. 2018, Jørgensen et al. 2013, Chan et al. 2014 |
| SPOP | Hedgehog signaling pathway | ||
| SRSF2 | RNA metabolism pathway | ||
| STAT6 | Autocrine; paracrine | JAK–STAT signaling pathway | Olsan et al. 2011, Passerini et al. 2018 |
| TGFBR2 | Paracrine; endocrine | TGF‐β signaling pathway | Li et al. 2009b, Busch et al. 2015 |
| TP53 | Endocrine | MAPK signaling pathway; p53 signaling pathway; PI3K‐Akt signaling pathway; Wnt signaling pathway | Rieber and Strasberg‐Rieber 2014 |
| ZNF521 | Endocrine | Cell cycle pathway | Addison et al. 2014 |