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Pharmacokinetic profile of BI 655088 and BI 655089.
| Parameter | BI 655088 Mean (SD) |
BI 655089 Mean (SD) |
|---|---|---|
| 0.2 mg/kg i.v. | ||
| CL (mL/d/kg) | 112.6 (24.9) | 145.6 (28.9) |
| AUCinf (nM * h) | 1126 (249) | 438 (91) |
| T1/2 (d) | 1.3 (0.2) | 0.4 (0.1) |
| 2 mg/kg i.v. | ||
| CL (mL/d/kg) | 9.4 (1.2) | 92 (29.8) |
| AUCinf (nM * h) | 155841 (9732) | 7040 (1957) |
| T1/2 (d) | 9.2 (2.1) | 1.8 (0.5) |
| 2 mg/kg s.c. | ||
| AUCinf (nM * h) | 73530 (10583) | 10713 (1770) |
| F% | 55.2 (7.9) | >100% |
