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. 2019 Oct 13;17(2):211–226. doi: 10.1080/15476286.2019.1673657

Figure 2.

Figure 2.

Consistently dysregulated RBPs across 16 human cancer types. (A) directionality and amplitude of the expression change in tumour compared with normal for each RBP. The X axis represents the directionality that is defined by the number of cancer types RBP showing upregulated expression minus that showing downregulated expression. The Y-axis is the average of the fold change across 16 cancer types. cuRBPs and cdRBPs were within the area with green and blue colour respectively. SUR and significantly dysregulated RBPs defined in the previous study were marked with red and blue colours. RBPs pointed by yellow colour arrows are RBPs showing bidirectional expression changes across cancer, while RBPs pointed by red arrows are examples showing consistently dysregulation but not included in significantly dysregulated RBPs. (B) and (C) Heatmap illustrating expression fold change of 41 cdRBPs and 109 cuRBPs, respectively. The colour key illustrating the log2 fold change of gene expression between tumour and normal. RBPs mentioned in the main text were marked in red.