Table 2.
Risk factors for DKA associated with SGLT inhibitor therapy
| Risk level for DKA | Factor |
|---|---|
| Moderate/high | • Reduced basal insulin by more than 10–20% |
| • Insulin pump or infusion site failure | |
| • Reduced or inconsistent carbohydrate intake | |
| • Excessive alcohol use | |
| • Use of illicit drugs | |
| • Volume depletion/dehydration | |
| • Acute illness of any sort (viral or bacterial) | |
| • Vomiting | |
| Low/moderate | • Vigorous or prolonged exercise |
| • Reduced prandial insulin dose by more than 10–20% | |
| • Travel with disruption in usual schedule/insulin regimen | |
| • Insulin pump use | |
| Minimal/low | • Low BMI (<25 kg/m2) |
| • Inconsistent caloric intake | |
| • Moderate alcohol use* | |
| • Female sex |
*
If ketone levels increase from baseline.