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. 2019 Mar 12;14(1):7–19. doi: 10.5009/gnl18203

Fig. 3.

Fig. 3

Mechanism of action of aminosalicylates (5-ASAs) in inflammatory bowel disease.

PPARγ, peroxisome proliferator-activated receptor γ; NF-kB, nuclear factor-kB; TLR, Toll-like receptor; COX, cyclooxygenase; LOX, lipoxygenase; PG, prostaglandin; LT, leukotriene. Modified from Nakase H. To master the optimal therapy for ulcerative colitis. Tokyo: Igakutokangosha Co., Ltd., 2018, with permission.2