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Mechanism of action of tacrolimus.
NFAT, nuclear factor of activated T cells; NFATp, NFATc1 and NFATc2; NFATn, NFAT in the nucleus; P, phosphoric acid; FKBP-12, FK-binding protein 12; IL, interleukin; IFN, interferon; GM-CSF, granulocyte macrophage colony-stimulating factors; TNF, tumor necrosis factor. Modified from Nakase H. To master the optimal therapy for ulcerative colitis. Tokyo: Igakutokangosha Co., Ltd., 2018, with permission.2
