Table 2. Ongoing phase 3 clinical trials on ClinicalTrials.gov on particle radiotherapy.
| ClinicalTrials.gov Identifier | Cancer | Intervention | Comparator | Country | Start date Estimated end date |
Primary endpoint |
|---|---|---|---|---|---|---|
| NCT03186898 | Liver | Proton RT | Photon RT | USA | June 2017 August 2022 |
OS |
| NCT01182753 | Chondro-sarcoma | Carbon ion RT | Proton RT* | Germany | August 2010 August 2022 |
5-Year LPFS |
| NCT01182779 | Chordoma | Carbon ion RT | Proton RT* | Germany | August 2010 August 2023 |
8-Year LPFS |
| NCT03801876 | Oesophage | Proton RT | IMRT | USA | March 2019 February 2027 |
OS |
| NCT01993810 | Lung | Proton RT | Photon RT | USA | February 2014 December 2020 |
OS |
| NCT02838602 | Radio-resistant | Carbon ion RT | Proton RT* IMRT |
France | December 2017 November 2023 |
5-Year PFS |
| NCT01893307 | Oro-pharynx | IMPT | IMRT | USA | August 2013 August 2023 |
Toxicity |
RT, radiotherapy; IMRT, Intensity-Modulated Photon Therapy; IMPT, Intensity-Modulated Proton Beam Therapy; OS, overall survival; LPFS, Local-Progression Free Survival; PFS, Progression-Free Survival
*
reference comparator is proton NOT photon radiotherapy