Extended Data Table 1. Expression of CSP family in Western Africa.

Microarray fold change data from microarray datasets retrieved from IR-TEx¹⁰ across Western Africa for An. coluzzii and An. gambiae populations for each member of the CSP family. Highlighted in green are fold changes showing significant overexpression in the respective datasets, and yellow under expression; white backgrounds show no significant change. SAP2 is emboldened. The country of origin, species and exposure status of the resistant population are given below each table, as well as the susceptible population used as a comparator.

Dataset		Banfora	Tiefora13	Tiefora14	Tensrela	VK72011	VK72012	VK6
AGAP008051-RA	SAP1	0.827	3.320	5.414	2.229	2.006	0.370	0.402
AGAP008052-RA	SAP2	2.218	2.947	7.912	6.102	6.322	0.953	0.949
AGAP008054-RA	SAP3	1.040	0.882	0.736	1.052	1.729	0.858	1.329
AGAP008055-RA	CSP3	0.960	2.516	1.994	3.086	3.866	0.914	1.419
AGAP008058-RA	CSP5	1.060	1.252	1.824	1.074	1.231	0.649	0.997
AGAP008059-RA	CSP1	0.506	3.628	4.146	1.738	1.247	0.466	0.877
AGAP008062-RA	CSP4	0.921	0.992	1.024	0.948	1.048	0.985	1.162
AGAP001303-RA	CSP6	0.869	1.772	2.118	0.961	0.704	0.463	0.782
AGAP001303-RB	CSP6	0.864	1.821	2.164	0.969	0.711	0.444	1.195
Country		Burkina Faso	Burkina Faso	Burkina Faso	Burkina Faso	Burkina Faso	Burkina Faso	Burkina Faso
Species		An. coluzzii	An. gambiae	An. gambiae	An. coluzzii	An. coluzzii	An. coluzzii	An. coluzzii
Exposure Status		Unexposed	Unexposed	Unexposed	Unexposed	Deltamethrin	Deltamethrin	Unexposed
Susceptible Comparator		N'Gousso	Kisumu	Kisumu	Mali	Mali	N'Gousso	N'Gousso
Dataset		Bouake	M'Be	Tiassale	TiassaleMali	TiassaleOkyero	Tiassale2011	Nkolondom
AGAP008051-RA	SAP1	1.889	1.726	4.257	1.106	0.620	0.385	1.374
AGAP008052-RA	SAP2	10.486	8.882	51.346	1.360	0.419	0.768	1.415
AGAP008054-RA	SAP3	2.585	1.683	5.516	0.822	0.623	0.681	1.844
AGAP008055-RA	CSP3	1.157	1.549	1.247	1.091	0.672	0.569	2.259
AGAP008058-RA	CSP5	0.946	1.134	1.008	1.038	0.833	0.688	1.330
AGAP008059-RA	CSP1	1.609	1.932	2.505	1.067	0.844	0.638	1.331
AGAP008062-RA	CSP4	0.992	0.980	0.995	1.076	0.990	1.128	1.100
AGAP001303-RA	CSP6	0.610	0.635	0.856	0.848	1.130	0.456	2.384
AGAP001303-RB	CSP6	0.584	0.604	0.819	0.850	1.065	0.458	2.463
Country		Cote D‘Ivoire	Cote D‘Ivoire	Cote D‘Ivoire	Cote D‘Ivoire	Cote D‘Ivoire	Cote D‘Ivoire	Cameroon
Species		An. coluzzii	An. coluzzii	An. coluzzii	An. coluzzii	An. coluzzii	An. coluzzii	An. gambiae
Exposure Status		Deltamethrin	Deltamethrin	Deltamethrin	Unexposed	Unexposed	Unexposed	DDT
Susceptible Comparator		N'gousso	N'gousso	N'gousso	Mali	Okyero	N'Gousso	Kisumu
Dataset		Garre	Messa	Youande	Bioko	KovieOkyero	KovieMalanville
AGAP008051-RA	SAP1	0.659	0.702	0.978	0.782	1.171	0.519
AGAP008052-RA	SAP2	3.024	1.673	2.009	4.094	0.871	0.473
AGAP008054-RA	SAP3	1.480	1.842	1.412	0.962	0.605	0.065
AGAP008055-RA	CSP3	1.023	0.795	0.952	0.754	0.723	0.844
AGAP008058-RA	CSP5	0.774	0.681	1.298	0.734	0.842	0.956
AGAP008059-RA	CSP1	0.481	0.492	1.297	0.472	1.535	1.293
AGAP008062-RA	CSP4	0.958	0.870	0.993	0.848	1.821	0.826
AGAP001303-RA	CSP6	0.452	0.423	1.387	0.458	1.135	0.896
AGAP001303-RB	CSP6	0.450	0.393	1.431	0.435	1.232	0.908
Country		Cameroon	Cameroon	Cameroon	Equatorial Guinea	Togo	Togo
Species		An. coluzzii	An. coluzzii	An. gambiae	An. coluzzii	An. coluzzii	An. coluzzii
Exposure Status		DDT	DDT	Bendiocarb	Deltamethrin	Unexposed	Unexposed
Susceptible Comparator		N'Gousso	N'Gousso	N'Gousso	N'gousso	Okyero	Malanville