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. 2020 Jan 10;96(1):10–31. doi: 10.2183/pjab.96.002

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© 2020 The Japan Academy

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — (Color online) SIK3 and ion channels related to sleep changes. A. KCNA2 has 6 transmembrane segments and the selective filter formed by a TVGYG sequence. B. CACNA1A is composed of four repeats of 6 transmembrane segments and has a selective filter motif of EEEE. The substitution of F102 to L decreased the time spent in wakefulness in Drowsy mutants. C. NALCN has four repeats of 6 transmembrane domains and has the selective filter motif of EEKE. The substitution of N315 to K caused abnormal REM sleep in Dreamless mutants. D. Wild-type murine SIK3 has a kinase domain and protein kinase A (PKA)-phosphorylation site, S551. E. Slp mutant SIK3 lacks the exon13-encoded region. F. Serine 551 of SIK3 is substituted with alanine. G. Drosophila SIK3 orthologue has a PKA-phosphorylation site, S563, equivalent to murine S551. H. C. elegans SIK3 orthologue, kin-29 has the PKA-phosphorylation site, S517.