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. 2020 Jan 15;11:342. doi: 10.3389/fnagi.2019.00342

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Copyright © 2020 Atluri, Tiwari, Rodriguez, Kaushik, Yndart, Kolishetti, Yatham and Nair.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cytokine release inhibitory drug (CRID3) inhibits Caspase-1 and IL-1β protein expression. SH-APP cells were co-cultured with CHME5 microglia cell line (microglia: neuron ratio of 1:2) in the presence of CRID3 (25–100 nM) for 48 h. Cells were harvested and the cell pellet was used in western blot for Caspase-1 (A) and IL-1β (B) protein expression analysis. Relative protein expression was calculated using ImageJ and a significant inhibition was observed for Caspase-1 (C) and IL-1β (D) protein expression at 100 nM CRID3 concentration compared to the water-treated control cells (n = 3) (^∗∗p ≤ 0.01; ^∗∗∗p ≤ 0.001).