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Mithramycin A (MTM) inhibits histone deacetylase 2 (HDAC2) expression. Amyloid overexpressing cells (SH-APP) were exposed to different concentrations of MTM and found that at 0.25 μM concentration significantly inhibits both HDAC2 gene (A) and protein (B) expression (∗∗p ≤ 0.01; ∗∗∗p ≤ 0.001).
