Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jan 15;10:1584. doi: 10.3389/fphys.2019.01584

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Nagy, Pethő, Gáll, Zavaczki, Nyitrai, Posta, Zarjou, Agarwal, Balla and Balla.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Prolyl hydroxylase inhibitor (PHI) FG4592 decreases smooth muscle marker expression that is prevented by zinc. VSMCs were cultured in growth medium in the presence or absence of PHI (5 and 20 μmol/L) or in calcification medium with or without PHI FG4592 and zinc for 10 days, and the expression of smooth muscle-specific markers were measured using qRT-PCR (A–C). (A) Relative expression of ACTA-2 (smooth muscle alpha (α)-2 actin), (B) MYH11 (smooth muscle myosin heavy chain 11), and (C) TAGLN (smooth muscle protein 22-α) were determined by qRT-PCR and normalized to RNA45S5. Results are presented as mean ± SEM of three independent experiments. Statistical analysis was performed by one-way ANOVA test followed by Bonferroni correction. A value of p < 0.05 was considered significant. ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001.