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. 2020 Jan 15;10:3048. doi: 10.3389/fimmu.2019.03048

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Copyright © 2020 Yang, Wang, Xie, Li, Wang, Wan and Zhong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of DGKα and ζ double deficiency on T_H lineage-specific transcription factors. (A,B) Tbx21 mRNA (A) and T-bet protein (B) levels in CD4⁺ T cells during T_H1 polarization. (C) Relative mRNA level of GATA-3 in CD4⁺ T cells during T_H2 polarization. (D,E) RORc mRNA (D) and RORγt protein (E) levels in CD4⁺ T cells during T_H17 polarization. (F) Relative RORa mRNA levels in CD4⁺ T cells during T_H17 polarization. Data shown are representative of five independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001 determined by the Student t-test.