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. 2020 Jan 15;11:36. doi: 10.3389/fnsyn.2019.00036

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Copyright © 2020 Bornschein, Brachtendorf and Schmidt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Young synapses have lower efficacy during bursting activity than mature synapses. (A) Top: examples of 10 consecutive EPSC trains each induced by 50 ACs at 20 ms ISIs in the presynaptic neuron of a P10 mouse. Bottom: median EPSC amplitudes and IQRs from young L5PN pairs (n = 14) normalized to first amplitudes (A1, double-exponential fit in black, IQR in gray). (B) As in (A), but for mature L5PNs (n = 7). (C) Ai/A1 ratios are significantly higher in mature than in young L5PNs for the first seven EPSCs (2nd: *P = 0.012, 3rd+4th: ***P < 0.001, 5th: **P = 0.009, 6th: *P = 0.028, 7th: *P = 0.015; MWU test). (D) Synaptic failures (F_syn) during the train occurred significantly earlier and more often in young than in mature connections following the third activation (*P < 0.05, **P < 0.01, ***P < 0.001; MWU test).