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1C6 × Rag1−/− mice develop severe MOG[35−55]-driven EAE. 1C6 (male, n = 4; female, n = 5) and 1C6 × Rag1−/− (male, n = 4; female, n = 5) mice were actively immunized with MOG[35−55] and were monitored for signs of EAE. (A) female, (B) male. *p < 0.05; !p < 0.001, two-tailed Mann-Whitney U test. ϕ indicates that all mice in the experimental group attained ethical endpoints. Representative of three immunizations.
