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. 2020 Jan 15;11:368. doi: 10.3389/fnagi.2019.00368

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Copyright © 2020 Adler, Chiang, Mayne, Ning, Zhang, Xu, Cheng and Figeys.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Aging disrupts the circadian regulation of proteins involved in synaptic function in the hippocampus. (A) Schematic depiction of proteins involved in synaptic structure and function, including the synaptic vesicle cycle, LTP and AMPAR regulation, and the cytoskeleton. Proteins that displayed loss or gain of circadian rhythmicity in abundance during aging are highlighted in color. Proteins that were reliably quantified, but not detected as circadian at either age, are shown in gray. (B) Temporal abundance profiles of rhythmic proteins identified in young mice involved in synaptic structure and function.