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Cytotoxicity profiles of IMB-0283 compared with those of DCS.
| Compound | MTBH37Rv |
HepG2 |
Vero |
||
| MIC (μg/mL) | TC50 (μg/mL) | SI | TC50 (μg/mL) | SI | |
| DCS | 16 | 1380 | 86.25 | 2044 | 127.75 |
| IMB-0283 | 0.5 | 115.4 | 230.8 | 249.8 | 499.6 |
DCS, D-cycloserine; MIC, minimum inhibitory concentrations; SI, selective index which was calculated via TC50/MIC.
