FIG 2.

IgG antigenic landscapes of adults and children pre- and postexposure. Influenza virus protein microarray (IVPM) AUC values and amino acid sequences were used to generate antigenic landscapes using multidimensional scaling. The z axis represents reactivity to a substrate (AUC as geometric mean titer), and the x and y axes represent amino acid differences between HAs used as the substrate. The gray plane under each of the red and blue planes represents the preexposure reactivity, the blue plane represents the postexposure group 1 reactivity, and the red plane represents the postexposure group 2 reactivity. The different strains/subtypes are indicated by colored spheres labeled with the substrate name. (A) PCR⁺ adults. (B) PCR⁻ adults. (C) PCR⁺ children. (D) PCR⁻ children. (E and F) Shown are the same data in a heat map and the fold induction in a heat map format (F) (as geometric mean induction).