Table 2.

Gene pathway enrichment of heritable genes in certain gene pathways (KEGG, REACTOME, BIOCARTA) and genes identified in GWAS for immune diseases, mental or behavioral disorders, cardiovascular diseases, or cancer (extracted from the GWAS catalog [25])

	h2res enrichment p-value	h2cis enrichment p-value
All immune-related GWAS genes	4.99 × 10−13	6.71 × 10−4
All immune-related GWAS genesa	2.33 × 10−10	9.13 × 10−5
All psychiatric-related GWAS genes	1.79 × 10−7	7.13 × 10−4
All psychiatric-related GWAS genesa	3.63 × 10−10	2.36 × 10−3
All cancer-related GWAS genes	5.53 × 10−5	1.09 × 10−7
All cancer-related GWAS genesa	7.10 × 10−6	3.15 × 10−7
All cardiovascular GWAS genes	1.06 × 10−9	3.24 × 10−5
All cardiovascular GWAS genesa	9.69 × 10−10	1.16 × 10−5
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	4.22 × 10−15
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTIONa	6.66 × 10−15
KEGG_LYSOSOME		1.41 × 10−7
KEGG_LYSOSOMEa		5.79 × 10−9

^ah² corrected for median read count. See also Supplementary Table 5.