Table 3.

Predictors of h²

	h2res			h2cis
Predictor	Estimate	P-value	r-squared	Estimate	P-value	r-squared
Median Read count	5.21 × 10−2	6.81 × 10−276	1.16 × 10−1	−3.76 × 10−3	2.15 × 10−2	8.16 × 10−4
	NA	NA	NA	NA	NA	NA
GC content	3.10 × 10−3	1.80 × 10−115	4.81 × 10−2	1.58 × 10−3	4.02 × 10−26	8.85 × 10−3
GC contenta	2.27 × 10−3	1.07 × 10−69	2.83 × 10−2	1.64 × 10−3	6.11 × 10−28	9.85 × 10−3
LOF score	7.24 × 10−3	8.16 × 10−18	3.14 × 10−2	−3.19 × 10−3	8.52 × 10−5	2.55 × 10−3
LOF scorea	−1.65 × 10−4	8.04 × 10−1	3.95 × 10−6	6.10 × 10−4	4.08 × 10−1	6.18 × 10−5
pLI score	3.54 × 10−2	7.09 × 10−19	2.47 × 10−2	−2.37 × 10−2	1.27 × 10−9	7.41 × 10−3
pLI scorea	−1.73 × 10−3	5.98 × 10−1	1.50 × 10−5	−3.00 × 10−3	4.13 × 10−1	1.29 × 10−4
pNull	−4.59 × 10−2	2.86 × 10−17	2.54 × 10−2	1.72 × 10−2	6.30 × 10−4	1.90 × 10−3
pNulla	−4.31 × 10−3	2.99 × 10−1	7.50 × 10−5	−3.54 × 10−3	4.45 × 10−1	7.75 × 10−5
pRec	−1.30 × 10−2	3.25 × 10−3	1.43 × 10−3	1.58 × 10−2	1.96 × 10−4	3.34 × 10−3
pReca	−1.64 × 10−3	6.50 × 10−1	5.74 × 10−5	7.37 × 10−3	6.62 × 10−2	4.33 × 10−4
Gene length	1.80 × 10−8	8.10 × 10−2	2.12 × 10−4	9.54 × 10−9	3.86 × 10−1	2.30 × 10−4
Gene lengtha	4.94 × 10−8	4.13 × 10−7	2.26 × 10−3	7.48 × 10−9	4.96 × 10−1	1.59 × 10−4

We tested whether h² could be predicted by gene expression level, gene length, GC content or several loss-of-function scores obtained from Lek et al. [22]

LOF loss-of-function, PLI probability of loss-of-function, pNull completely tolerant of loss-of-function, pRec intolerant of two loss-of-function variants

^ah² corrected for median read count