Table 2.
Multivariate analysis
| APC or Biallelic MUTYH | APC | Biallelic MUTYH | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Na | OR (95% CI) | P-value | Na | OR (95% CI) | P-value | Na | OR (95% CI) | P-value | |
| Adenoma count | |||||||||
| <10 | 188 | Ref | <0.001 | 205 | Ref | <0.001 | 296 | Ref | <0.001 |
| 10–19 | 292 | 2.6 (0.8–8.0) | 296 | 8.5 (0.8–88.9) | 367 | 1.5 (0.5–4.7) | |||
| 20–49 | 486 | 12.9 (5.0–33.3) | 502 | 39.2 (4.7–324.2) | 515 | 6.3 (2.6–15.1) | |||
| 50–99 | 114 | 15.5 (5.5–43.8) | 115 | 32.5 (3.6–289.9) | 116 | 10.8 (4.0–29.1) | |||
| >100 | 264 | 59.4 (22.4–157.2) | 275 | 289.9 (35.2–2385.2) | 269 | 3.5 (1.3–9.5) | |||
| Age at adenoma diagnosis | |||||||||
| >60 | 486 | Ref | <0.001 | 502 | Ref | <0.001 | 608 | Ref | <0.001 |
| 50–59 | 328 | 5.1 (2.7–9.5) | 335 | 3.3 (1.3–8.4) | 370 | 3.9 (2.0–7.6) | |||
| 40–49 | 235 | 14.5 (6.8–31.0) | 248 | 12.0 (4.6–31.4) | 260 | 5.5 (2.3–13.5) | |||
| 30–39 | 164 | 11.4 (5.3–24.8) | 172 | 12.6 (4.9–32.7) | 188 | 3.9 (1.4–10.6) | |||
| <30 | 131 | 18.7 (8.4–41.4) | 136 | 33.1 (12.5–87.5) | 137 | 0.9 (0.2–3.7) | |||
| CRC (age) | |||||||||
| No | 920 | Ref | 0.006 | 951 | Ref | 0.003 | 1065 | Ref | <0.001 |
| <40 | 56 | 1.3 (0.6–3.0) | 58 | 0.6 (0.3–1.3) | 63 | 3.9 (1.5–10.0) | |||
| 40–50 | 111 | 1.3 (0.7–2.5) | 115 | 0.3 (0.1–0.6) | 123 | 4.5 (2.2–9.0) | |||
| >50 | 257 | 2.6 (1.5–4.5) | 269 | 0.5 (0.2–1.1) | 312 | 5.1 (2.8–9.2) | |||
| FDR with polyps | |||||||||
| No | 809 | Ref | <0.001 | 834 | Ref | <0.001 | 945 | Ref | 0.098 |
| Yes, ≤10 polyps | 140 | 0.5 (0.2–1.0) | 153 | 1.5 (0.7–3.3) | 191 | 0.3 (0.1–0.8) | |||
| Yes, >10 polyps | 184 | 4.5 (2.6–8.0) | 191 | 4.5 (2.5–8.4) | 194 | 1.2 (0.6–2.3) | |||
| Yes, number unknown | 211 | 0.4 (0.2–0.7) | 215 | 0.4 (0.2–0.8) | 233 | 0.8 (0.5–1.5) | |||
| FDR with CRC | |||||||||
| No | 812 | Ref | 0.007 | 842 | Ref | 0.155 | 923 | Ref | 0.193 |
| Yes, ≤50 y | 132 | 1.3 (0.7–2.4) | 140 | 1.0 (0.5–2.1) | 157 | 1.5 (0.8–2.9) | |||
| Yes, >50 y | 349 | 0.5 (0.3–0.8) | 358 | 0.6 (0.3–1.0) | 426 | 0.7 (0.4–1.3) | |||
| Yes, age unknown | 51 | 1.6 (0.6–4.3) | 53 | 2.0 (0.7–6.0) | 57 | 0.7 (0.2–2.3) | |||
| Year of DNA testing | |||||||||
| 2012–2017 | 401 | Ref | <0.001 | 415 | Ref | <0.001 | 511 | Ref | 0.006 |
| 2006–2011 | 511 | 1.7 (1.0–3.0) | 521 | 2.0 (1.0–4.3) | 591 | 1.1 (0.5–2.7) | |||
| 2000–2005 | 266 | 3.9 (2.2–7.2) | 280 | 2.5 (1.2–5.4) | 291 | 2.3 (1.2–4.7) | |||
| <1995–1999 | 166 | 9.8 (4.7–20.3) | 177 | 9.6 (4.1–22.2) | 170 | 1.0 (0.5–2.0) | |||
aNumbers are without cases with missing information