Table 1.

Derivation of global point prevalence from case reports; family reports; preestablished ranges and numerical values. a Total number of cases divided by the worldwide population (7 550 000 000); b indirect point prevalence increases 1.6 if number of cases = number of families × 10; 1.2 used for all further calculations; c minimum and maximum boundaries

Indicators	Rare diseases		Number of cases	Point prevalence estimates per 100 000
	Number	%
Cases/families reports
Cases	2496	69.6	85 680	–
Families	344	9.6	3 418	–
Prevalence
Indirect point prevalence (a)	2840	79.2	89 098	1.2 (b)
Point prevalence	745	20.8	–	3 481.1–5 909.1 (c)
Total (sum)	3585	100	–	3 482.3–5 910.3