Table 7.
Drug susceptibility profiles of M. kansasii strains under the study.
| Typea | MIC [mg/L] ofb | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Strain no. | RIF | CLR | INH | EMB | STR | AMK | SXT | RFB | MXF | LZD | CIP | DOX | ETO | ||
| M. kansasii | I (11) | NLA001000521 | 0.25 | 0.25 | 2 | >16 | 8 | 2 | <0.12 | <0.25 | <0.12 | 2 | 2 | 4 | <0.3 |
| ATCC25221 | 0.25 | 0.12 | 2 | 16 | 4 | 2 | <0.12 | <0.25 | <0.12 | 2 | 1 | 4 | 0.6 | ||
| NLA001000927 | 0.25 | 0.12 | 2 | 16 | 4 | 1 | <0.12 | <0.25 | <0.12 | 1 | 1 | 4 | 0.6 | ||
| NLA001000449 | 0.25 | >64 | 2 | >16 | 8 | 4 | <0.12 | <0.25 | <0.12 | 2 | 2 | 8 | <0.3 | ||
| 6200 | 0.25 | 0.25 | 2 | >16 | 8 | 2 | 0.12 | <0.25 | <0.12 | 2 | 2 | 16 | <0.3 | ||
| 7728 | 1 | 0.5 | 2 | >16 | 16 | 8 | 0.12 | <0.25 | 0.25 | 4 | 4 | >16 | <0.3 | ||
| 7744 | 1 | 0.12 | 1 | >16 | 4 | 2 | <0.12 | <0.25 | <0.12 | <1 | 1 | 4 | <0.3 | ||
| 1010001495 | 0.25 | 0.12 | 2 | 16 | 8 | 2 | <0.12 | <0.25 | <0.12 | <1 | 1 | 4 | <0.3 | ||
| K4 | 0.5 | 0.25 | 2 | >16 | 4 | 2 | 0.12 | <0.25 | <0.12 | 2 | 1 | 4 | <0.3 | ||
| K14 | 1 | 0.5 | 2 | >16 | 8 | 4 | 0.12 | <0.25 | <0.12 | 2 | 1 | 8 | <0.3 | ||
| K19 | 0.5 | 0.25 | 1 | >16 | 4 | 2 | 0.12 | <0.25 | <0.12 | 2 | 0.5 | 4 | <0.3 | ||
| MIC50/90 | 0.25/1 | 0.25/0.5 | 2/2 | >16/>16 | 8/8 | 2/4 | <0.12/<0.12 | <0.25/<0.25 | <0.12/<0.12 | 2/2 | 1/2 | 4/16 | <0.3/0.6 | ||
| MIC range | 0.25-1 | 0.12->64 | 1-2 | 16->16 | 4-16 | 1-8 | <0.12-0.12 | <0.25 | <0.12–0.25 | <1–4 | 0.5–4 | 4–>16 | <0.3–0.6 | ||
| M. persicum | II (7) | 2193 | 0.5 | 0.12 | 1 | 16 | 2 | <1 | <0.12 | <0.25 | <0.12 | <1 | 0.25 | 2 | <0.3 |
| NLA001001128 | 1 | 0.25 | 1 | >16 | 16 | 8 | <0.12 | <0.25 | <0.12 | 4 | 2 | 8 | <0.3 | ||
| B11073207 | 0.25 | 0.12 | 1 | 16 | 4 | 2 | <0.12 | <0.25 | <0.12 | 2 | 0.5 | 4 | <0.3 | ||
| B11063838 | 1 | 0.5 | 1 | >16 | 8 | 4 | <0.12 | <0.25 | <0.12 | 2 | 1 | 16 | <0.3 | ||
| 1010001469 | 1 | 0.12 | 1 | >16 | 16 | 2 | <0.12 | <0.25 | <0.12 | 2 | 2 | 8 | <0.3 | ||
| H47 | 1 | 0.5 | 2 | >16 | 4 | 2 | 0.12 | <0.25 | 0.25 | 2 | 1 | 8 | 0.6 | ||
| H48 | 0.25 | 1 | 1 | >16 | 8 | 8 | 2 | <0.25 | <0.12 | 4 | 1 | 8 | <0.3 | ||
| MIC50/90 | 1/1 | 0.25/1 | 1/2 | >16/>16 | 8/16 | 2/8 | <0.12/2 | <0.25/<0.25 | <0.12/0.25 | 2/4 | 1/2 | 8/16 | <0.3/0.6 | ||
| MIC range | 0.25–1 | 0.12–1 | 1–2 | 16/>16 | 2–16 | <1–8 | <0.12–2 | <0.25 | <0.12–0.25 | <1–4 | 0.25–2 | 2–16 | <0.3–0.6 | ||
| M. pseudokansasii | III (4) | 14_15 | <0.12 | 0.12 | 1 | >16 | 4 | 4 | 0.5 | <0.25 | <0.12 | 2 | 1 | 1 | <0.3 |
| 174_15 | 0.12 | 0.12 | 2 | >16 | 8 | 2 | <0.12 | <0.25 | <0.12 | 2 | 2 | 4 | <0.3 | ||
| 1010001468 | 0.5 | <0.06 | 1 | 16 | 4 | <1 | <0.12 | <0.25 | <0.12 | <1 | 0.5 | 2 | <0.3 | ||
| MK142 | 0.25 | 0.25 | 0.5 | 1 | 2 | <1 | <0.12 | <0.25 | 0.25 | <1 | 4 | 4 | <0.3 | ||
| MIC50/90 | 0.12/0.5 | 0.12/0.25 | 1/2 | 16/>16 | 4/8 | <1/4 | <0.12/0.5 | <0.25/<0.25 | <0.12/0.25 | <1/2 | 1/2 | 2/4 | <0.3/<0.3 | ||
| MIC range | <0.12–0.5 | <0.06–0.25 | 0.5–2 | 1–>16 | 2–8 | <1–4 | <0.12–0.5 | <0.25 | <0.12–0.25 | <1–2 | 0.5–4 | 1–4 | <0.3 | ||
| M. ostraviense | IV (2) | 1010001458 | <0.12 | <0.06 | 1 | 16 | 4 | 2 | 0.12 | <0.25 | <0.12 | <1 | 0.5 | 4 | <0.3 |
| 241/15 | <0.12 | 0.06 | 2 | >16 | 4 | 4 | 0.12 | <0.25 | <0.12 | 2 | 2 | 2 | <0.3 | ||
| MIC50/90 | <0.12/<0.12 | <0.06/0.06 | 1/2 | 16/>16 | 4/4 | 2/4 | 0.12/0.12 | <0.25/<0.25 | <0.12/<0.12 | <1/2 | 0.5/2 | 2/4 | <0.3/<0.3 | ||
| MIC range | <0.12 | <0.06–0.06 | 1–2 | 16–>16 | 4 | 2–4 | 0.12 | <0.25 | <0.12 | <1–2 | 0.5–2 | 2–4 | <0.3 | ||
| M. innocens | V (4) | 1010001454 | 0.5 | <0.06 | 2 | 4 | 4 | 2 | 0.12 | <0.25 | <0.12 | 2 | 1 | 4 | <0.3 |
| 1010001493 | <0.12 | 0.12 | <0.25 | 4 | 4 | 2 | 0.12 | <0.25 | 0.25 | 2 | 2 | 4 | <0.3 | ||
| 49_11 | 0.5 | <0.06 | 1 | >16 | <0.5 | <1 | <0.12 | <0.25 | 0.5 | 4 | 2 | 8 | <0.3 | ||
| MK13 | <0.12 | 0.12 | <0.25 | 1 | 4 | 2 | 2 | <0.25 | 0.25 | <1 | 2 | 1 | <0.3 | ||
| MIC50/90 | <0.12/0.5 | <0.06/0.12 | <0.25/2 | 4/>16 | 4/4 | 2/2 | 0.12/2 | <0.25/<0.25 | 0.25/0.5 | 2/4 | 2/2 | 4/8 | <0.3/<0.3 | ||
| MIC range | <0.12–0.5 | <0.06–0.12 | <0.25–2 | 1–>16 | <0.5–4 | <1–2 | <0.12–2 | <0.25 | <0.12–0.5 | <1–4 | 1–2 | 1–8 | <0.3 | ||
| M. attenuatum | VI (2) | NLA001001166 | 0.25 | 0.12 | 2 | 16 | 8 | 1 | <0.12 | <0.25 | <0.12 | 2 | 1 | 8 | <0.3 |
| MK41 | 0.5 | 0.5 | 0.5 | 4 | 16 | 8 | <0.12 | <0.25 | 0.5 | <1 | 4 | >16 | <0.3 | ||
| MIC50/90 | 0.25/0.5 | 0.12/0.5 | 0.5/2 | 4/16 | 8/16 | 1/8 | <0.12/<0.12 | <0.25/<0.25 | <0.12/0.5 | <1/2 | 1/4 | 8/>16 | <0.3/<0.3 | ||
| MIC range | 0.25–0.5 | 0.12–0.5 | 0.5–2 | 4–16 | 8–16 | 1–8 | <0.12 | <0.25 | <0.12–0.5 | <1–2 | 1–4 | 8–>16 | <0.3 | ||
| TOTAL | MIC50/90 | 0.25/1 | 0.12/0.5 | 1/2 | >16/>16 | 4/16 | 2/8 | <0.12/0.12 | <0.25/<0.25 | <0.12–0.25 | 2/4 | 1/2 | 4/16 | <0.3/<0.3 | |
| MIC range | <0.12–1 | <0.06–>64 | <0.25–2 | 1–>16 | <0.5–16 | <1–8 | <0.12–2 | <0.25 | <0.12–0.5 | <1–4 | 0.25–4 | 1–>16 | <0.3–0.6 | ||
Please note, that for some isolates those data were reported elsewhere (Bakuła et al., 2018c).
a
According to the WGS-based (MiSI method) grouping. Vertically are given the newly proposed names for each of the M. kansasii subtypes.
b
RIF, rifampicin; CLR, clarithromycin; INH, isoniazid; EMB, ethambutol; STR, streptomycin; AMK, amikacin; SXT, co-trimoxazole; RFB, rifabutin; MXF, moxifloxacin; LZD, linezolid; CIP, ciprofloxacin; DOX, doxycycline; ETO, ethionamide.