Table 1.

HNV protein functions.

Function	Function
N	Nucleocapsid encasing viral genome
	Prevents STAT1 translocation (Sugai et al. 2017)
P	Component of RNA polymerase complex
	Sequestration of STAT1/2 (Shaw et al. 2004)
V	Block RIG-I/MDA5 signaling (Andrejeva et al. 2004; Sanchez-Aparicio et al. 2018)
	Inhibits NLRP3 inflammasome activation (Komatsu et al. 2018)
	Sequestration of STAT1/2 (Shaw et al. 2004)
W	Inhibits IRF3 phosphorylation (Shaw et al. 2005)
	Sequestration of STAT1/2 (Shaw et al. 2004)
	Inhibition of inflammatory responses (Satterfield et al. 2015)
C	Enhancement of virion budding (Park et al. 2016)
	Blocks IRF7 signaling (Yamaguchi et al. 2014)
M	Virion budding (Ciancanelli and Basler 2006; Patch et al. 2007)
	IFN antagonism (inhibits TRIM6 mediated IKKε ubiquitination) (Bharaj et al. 2016)
	Reduction of rRNA production (Rawlinson et al. 2018)
F	Fusion protein responsible for viral entry and syncytia formation (Tamin et al. 2002)
G	Attachment glycoprotein binds to ephrin-B2/B3 (Bonaparte et al. 2005; Negrete et al. 2005)
L	Viral RNA-dependent RNA polymerase (Harcourt et al. 2001)