Figure 2.
CerS expression declines age dependently in healthy human skeletal muscle and is further decreased in CHF patients. (a) Association between CerS 1, 2, 4, 5, and 6 mRNA expression in skeletal muscle and age in 41 healthy humans with a wide age range (20–56 years) by Pearson's correlation (r). CerS mRNA levels were normalized to endogenous HPRT mRNA expression. (b) mRNA expression profile of indicated CerS in skeletal muscle biopsies from six aged patients (age: 69.1 ± 12.5 years, sex (5m/1f), BMI 24.0 ± 2.2 kg/m2, peak VO2 23.2 ± 4.7 ml min−1 mg−1) suffering from chronic heart failure (CHF) compared with healthy controls (1f 83y; 1m 41y), normalized to endogenous GAPDH mRNA expression. Shown is a representative result (n = 3). Shown are means ± SD. Statistical significance was assessed by two‐tailed unpaired Student's t test, and exact p‐values are given