Figure 2.

NLRP3 signaling suppression in mice induces cardiac protection. (a) Heart weight normalized to body weight. (b) Representative image of centripetal concentric LV hypertrophy (c) Representative Hematoxylin and eosin (H&E)‐stained section (left) of cardiac tissues from young and old WT and NLRP3 −/− mice. Representative Masson trichrome‐stained section (center) and Sirius red‐stained section (right). (d) Quantitative analysis of cardiomyocyte cross‐sectional (transverse) area with measurements of ≈100 cardiomyocytes and fibrotic areas from 3 to 6 mice per group. ***p < .001 young vs. old mice. ^aaa p < .001, WT vs. NLRP3 −/− mice. (e) Summary of differences in PR and QRS intervals in young and aged WT vs. NLRP3 −/− mice. All data are presented as means ± SEM, n = 10 mice; *p < .05