Figure 6.

Schematic summary of osmolyte‐mediated cell volume response in aging skin. (a) Schematic summary of changes in human skin during intrinsic and extrinsic aging including reduced cell volume of epidermal keratinocytes in vivo, downregulation of osmolyte transporter proteins TAUT and SMIT in vivo, and downregulation of TAUT mRNA and protein in vitro. (b) Schematic summary of the taurine‐mediated improved cell volume regulatory mechanism in an in vitro model of aged epidermal keratinocytes. SMIT, sodium‐coupled myoinositol transporter; TAUT, taurine transporter