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. 2019 Nov 12;19(1):e13065. doi: 10.1111/acel.13065

Figure 1.

Figure 1

Premature aggregation of Q35::YFP in sel‐12 mutants is independent of gamma‐secretase protease activity. (a) Schematic representation of sel‐12 locus indicating the location of the mutation in the sel‐12 mutants analyzed in this study. (b) Representative images of wild‐type, sel‐12 (ar131), sel‐12 (ty11), sel‐12(ok2078), and D‐>A mutants expressing Q35::YFP (rmIs132) at day 1, day 3, and day 5 adulthood. Scale bar indicates 100 μm. (c and d) Quantification of Q35::YFP aggregation in wild‐type and sel‐12(ar131), sel‐12(ty11), sel‐12(ok2078), and sel‐12(D‐>A) animals at day 3 and day 5 adulthood (N = 30 animals per group). Data are displayed as mean ± SEM, and all comparisons have been made to wild‐type animals or indicated strains. ns p > .05, **p < .01, and ***p < .001 were determined using one‐way ANOVA