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. 2019 Nov 12;19(1):e13065. doi: 10.1111/acel.13065

Figure 2.

Figure 2

Proteostatic collapse in sel‐12 mutants is independent of gamma‐secretase protease activity. (a) Swimming assay of wild‐type, sel‐12(ty11), and sel‐12(D‐>A) animals expressing human Abeta1‐42 (dvIs100) was conducted by measuring the number of body bends in liquid (N = 20 animals per group). (b) Swimming assay of wild‐type, sel‐12(ty11), and sel‐12(D‐>A) animals expressing human V337M mutant tau were conducted by measuring the number of body bends in liquid (N = 20 animals per group). (c) Survival of day 1 animals after exposure to heat stress at 37°C for 1–4 hr (50 animals per group, done in triplicate). (d). Survival of day 1 mutants after exposure to heat stress at 37°C for 3 hr (50 animals per group, done in triplicate). Data are displayed as mean ± SEM, and all comparisons have been made to wild‐type animals or indicated strains. ns p > .05, **p < .01, and ***p < .001 were determined using one‐way ANOVA (a, b, and c) and two‐way ANOVA (c)