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. 2019 Nov 12;19(1):e13065. doi: 10.1111/acel.13065

Figure 5.

Figure 5

Antioxidant supplementation protects against proteostatic collapse in sel‐12 mutants. (a) Quantification of Q35::YFP aggregation of wild‐type, sel‐12(ar131), sel‐12(ty11) day 3 adult animals after exposure to TPP and MitoTEMPO (N = 20 animals per group). (b) Swimming assay was scored in wild‐type and sel‐12(ty11) day 1 adult animals expressing human Abeta1‐42 treated with 5 mM NAC by measuring the number of body bends in liquid (N = 20 animals in each group). (c) Swimming assay were scored in wild‐type and sel‐12(ty11) day 1 adult animals expressing human V337M mutant tau treated with 5 mM NAC by measuring the number of body bends in liquid (N = 20 animals in each group). (d) Survival of day 1 adult wild‐type, sel‐12(ar131), and sel‐12(ty11) mutant animals treated with 5 mM NAC after exposure to heat stress at 37°C for 2–4 hr (50 animals per group, done in triplicate). Data are displayed as mean ± SEM, and all comparisons have been made to wild‐type animals or indicated strains. ns p > .05, **p < .01, and ***p < .001 were determined using one‐way ANOVA (a, b, and c) and two‐way ANOVA (d)