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. 2020 Jan 21;18(1):1559325819901239. doi: 10.1177/1559325819901239

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — Exogenous miR-21 agomir caused abnormal new bone formation in the SIJ. A, Exogenous miR-21 caused SIJ bony ankylosis as evidenced by MRI (White arrows indicating fusions). B and C, Exogenous miR-21 caused bony ankylosis and new bone formation as detected via Micro-CT and HE staining (White arrows indicating fusions). D, Exogenous miR-21 agomir caused new bone formation by HE staining (white arrows indicating new bone formation). E, Exogenous miR-21 agomir caused SIJ fusion as evidenced by HE staining(white arrows indicating fusions). F, miR-21 antagomir did not cause SIJ new bone formation. G, miR-21 antagomir negative control did not cause SIJ new bone formation. H, Exogenous miR-21 agomir did not cause SIJ new bone formation in naïve control (6 mice for each group). CT indicates computed tomography; HE, hematoxylin and eosin; miR, MicroRNA; MRI, magnetic resonance imaging; SIJ, sacroiliac joint.