Fig. 2.

Comparison between healthy subjects and patients with bipolar disorder stratified according to lithium treatment duration. (a) 3D visualization of ANOVA results: right accumbens shell outward and left accumbens core inward deformations (in red) superimposed onto a representative nucleus accumbens mask (in blue); (b) Mean total deformation (distance from mean template, mm³) of right accumbens shell (light grey) and left accumbens core (orange) in patients with lithium treatment duration longer/shorter then 50% of illness duration (respectively, BD_LiTD+, BD_LiTD-), patients never treated with lithium (BD_NoLi) and healthy subjects (HC) groups. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)