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. 2020 Jan 15;9:1525. doi: 10.3389/fonc.2019.01525

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Copyright © 2020 Li, Li, Shi, Ahmed, Liu, Guo, Tang, Guo and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Oridonin induces apoptosis in esophageal cancer cell lines TE1 and EC109. (A) Chemical structure of oridonin. (B) EC109 and TE-1 cells were treated with different concentrations of oridonin or vehicle for 24, 48, and 72 h. The cell inhibition rate was determined using MTT assay, (C) IC50 values comparison between EC109 and TE-1 cells. (D) Fluorescence-activated cell sorting plots of Annexin V/PI-labeled cells treated with 10, 20, and 40 μM oridonin for 24 h. (E) The apoptosis rate is expressed as the mean ± SD (n = 3). The data were obtained from three independent experiments. *P < 0.05, **P < 0.01 compared to EC109 cell group.