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. 2020 Jan 15;9:1525. doi: 10.3389/fonc.2019.01525

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Copyright © 2020 Li, Li, Shi, Ahmed, Liu, Guo, Tang, Guo and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptome changes induced by oridonin using RNA-seq. (A) Venn diagram showing amounts of differentially expressed genes after treatment with oridonin for 4 h in EC109 cells and TE1 cells. (≥two-fold up/down-regulated, P < 0.01). (B) The “volcano plot” graph of the differentially expressed genes in EC109 and TE1 cells. (C) Verify RNAseq by qPCR analysis. TRIM16, TXNRD1, SRXN1, SLC7A11, GCLC, or GCLM and HSPA1A, HSPA1B, BAG3, DNAJB1, HSPH1 in EC109 cells and TE1 cells, respectively. Cells were treated with 30 μM oridonin or DMSO for 4 h. (D) Differentially expressed genes related to GSH in RNAseq. *P < 0.05, **P < 0.01 compared to DMSO group.