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Oridonin induced cytotoxicity by depleting intracellular GSH. (A,C) Viability (A), intracellular GSH content (B,C) were determined treated with oridonin in EC109 cells. (D-F) Viability (D), intracellular GSH content (E,F) were determined treated with oridonin in TE1 cells. (G-H) Viability at 24 h post-treatment with 1 mM GSH, 1 mM GSSG and/or 40 μM oridonin (EC109 cell) (G) or 30 μM oridonin (TE1 cell) (H). **P < 0.01, compared to treatment either of the compounds alone.
