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. 2020 Jan 15;13:1413. doi: 10.3389/fnins.2019.01413

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Copyright © 2020 Costa-Pereira, Ribeiro, Martins and Tavares.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nociceptive behavioral effects of the administration of clonidine (30 days after the first paclitaxel injection). (A,B) Show paw withdrawal thresholds in the von Frey test at baseline (T0) and 30 min (T30) after saline or clonidine administration. (D,E) Show paw withdrawal latencies in the cold plate test at T0 and T30 after saline or clonidine administration. (C,F) Show the percentage of change from baseline of paw withdrawal thresholds and latencies, in the von Frey (C) and cold plate (D) tests. Data are presented as mean ± SD (saline: DMSO n = 7; paclitaxel n = 6; clonidine at 0.1 μg: DMSO n = 6; paclitaxel n = 7; clonidine at 1 μg: DMSO n = 7; paclitaxel n = 7; clonidine at 10 μg: DMSO n = 8; paclitaxel n = 6). ^∗∗p < 0.01; ^∗∗∗p < 0.001; ^****p < 0.0001 vs. baseline (T0); ^##p < 0.01; ^###p < 0.001; ^####p < 0.0001 vs. saline. ⁺p < 0.05; ⁺⁺p < 0.01; ⁺⁺⁺⁺p < 0.0001 vs. clonidine 0.1 μg.