Table 2. Results of multivariate analyses of the presence and burden of cerebral atherosclerosis.
| FGF23 | Presence of cerebral atherosclerosis | |||||
|---|---|---|---|---|---|---|
| ICAS† | p | ECAS‡ | p | Both ECAS and ICAS§ | p | |
| Continuous variable, per 100 pg/mL | 1.07 (1.00–1.15) | 0.039 | 1.05 (0.99–1.12) | 0.073 | 1.10 (1.02–1.19) | 0.013 |
| Dichotomized based on median value of 182.0 pg/mL | 2.52 (1.36–4.68) | 0.003 | 1.59 (0.66–3.87) | 0.248 | Not available* | |
| Tertiles | ||||||
| Lower tertile, 0–146.79 pg/mL | Reference | Reference | Reference | |||
| Middle tertile, 146.79–235.16 pg/mL | 1.96 (0.93–4.12) | 0.076 | 1.97 (0.64–6.08) | 0.482 | Not available* | |
| Upper tertile, ≥235.16 pg/mL | 3.28 (1.53–7.05) | 0.002 | 1.26 (0.42–3.75) | 0.523 | Not available* | |
Data are odds ratio (95% CI) values.
*Odds ratio could not be obtained because the FGF23 concentrations of patients with both ECAS and ICAS exceeded 182.0 pg/mL, †Adjusted for sex, age, BMI, coronary artery disease, prestroke antithrombotics, stroke subtype, NIHSS score, high-grade WMHs, Klotho, triglyceride, WBC count, total calcium, and CRP, ‡Adjusted for sex, age, hypertension, stroke subtype, NIHSS score, high-grade WMHs, WBC count, phosphate, and uric acid, §Adjusted for sex, age, hypertension, prestroke antithrombotics, NIHSS score, high-grade WMHs, Klotho, triglyceride, WBC count, and CRP.
BMI: body mass index, ECAS: extracranial cerebral atherosclerosis, FGF23: fibroblast growth factor 23, ICAS: intracranial cerebral atherosclerosis, NIHSS: National Institutes of Health Stroke Scale, WBC: white blood cell, WMHs: white-matter hyperintensities.