Table 1. Modelled scenarios used in the transmission model.
Scenario | Description | |
---|---|---|
1 | Business as usual | • Continue all interventions at 2015 levels from 2016 through 2030 |
2 | Reverse scenario 1 | • Business as usual
• IRS activities ceased |
3 | Reverse scenario 2 | • Reverse scenario 1
• Distribution of new LLINs ceased |
4 | Reverse scenario 3 | • Reverse scenario 2
• Treatment rates reduced by 50% |
5 | Universal coverage | • Business as usual
• Coverage of population at risk with test and treat increased from 2017 onwards in a linear fashion over eight years to 80% by 2025 • Quinine is switched to injectable artesunate for management of severe disease in 2017 |
6 | IRS | • Universal coverage
• IRS coverage in 2017 doubled in a linear fashion over eight years |
7 | Effective usage | • Universal coverage
• Effectiveness of LLINs increased • Surveillance increased |
8 | New P. vivax treatment | • Effective usage
• Replace primaquine with a new P. vivax treatment |
9 | New LLINs | • New
P. vivax treatment
• Life of LLINs doubled |
10 | New
P. falciparum
treatment |
• New LLINs
• First-line Artemisin based Combiantion Therapy (ACT) replaced with new candidate for P. falciparum treatment |
Assumption | Description | |
A | Artemisinin and ACT
resistance |
5% probability of treatment failure from ACTs across all countries is constant until 2018 and then
increased to 30% through 2025 |
B | MDA | Five annual rounds of MDA at 50% coverage from 2018 starting four months before the peak of the
transmission season targeted at both species |
C | LLINs | Scaling up LLINs to 80% effective coverage deployed in a 3-year cycle (50%, 25% and 25%) |