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. 2020 Jan 14;4:60. Originally published 2019 Apr 1. [Version 2] doi: 10.12688/wellcomeopenres.14769.2

Table 1. Modelled scenarios used in the transmission model.

Scenario Description
1 Business as usual •   Continue all interventions at 2015 levels from 2016 through 2030
2 Reverse scenario 1 •   Business as usual
•   IRS activities ceased
3 Reverse scenario 2 •   Reverse scenario 1
•   Distribution of new LLINs ceased
4 Reverse scenario 3 •   Reverse scenario 2
•   Treatment rates reduced by 50%
5 Universal coverage •   Business as usual
•   Coverage of population at risk with test and treat increased from 2017 onwards in a linear fashion
   over eight years to 80% by 2025
•   Quinine is switched to injectable artesunate for management of severe disease in 2017
6 IRS •   Universal coverage
•   IRS coverage in 2017 doubled in a linear fashion over eight years
7 Effective usage •   Universal coverage
•   Effectiveness of LLINs increased
•   Surveillance increased
8 New P. vivax treatment •   Effective usage
•   Replace primaquine with a new P. vivax treatment
9 New LLINs •   New P. vivax treatment
•   Life of LLINs doubled
10 New P. falciparum
treatment
•   New LLINs
•   First-line Artemisin based Combiantion Therapy (ACT) replaced with new candidate for
    P. falciparum treatment
Assumption Description
A Artemisinin and ACT
resistance
5% probability of treatment failure from ACTs across all countries is constant until 2018 and then
increased to 30% through 2025
B MDA Five annual rounds of MDA at 50% coverage from 2018 starting four months before the peak of the
transmission season targeted at both species
C LLINs Scaling up LLINs to 80% effective coverage deployed in a 3-year cycle (50%, 25% and 25%)