Fig. 1.

Study design. All patients treated with IXE had a loading dose of 160 mg at week 0. ADA dose was 40 mg Q2W unless stated otherwise. ^aPatients determined to be inadequate responders by blinded criteria given adjustments to their background/existing therapy. Inadequate responders in the non-IXE groups randomized to IXE Q2W or IXE Q4W with washout for ADA inadequate responders. ^bResponders in ADA or PBO groups re-randomized to either IXE Q2W or IXE Q4W. ^cPatients randomized to IXE Q2W or PBO if they met the randomized withdrawal (RW) criteria (i.e., those who met Coates criteria for MDA for ≥ 3 consecutive months across ≥ 4 consecutive visits) at week 36 or later up to week 64. ^dPatients who had not met RW criteria at week 64 were given IXE Q2W; patients who relapsed (no longer met MDA criteria) during the double-blind withdrawal period were switched to, or continued, IXE Q2W. ADA Q2W: 40 mg of adalimumab every 2 weeks; IXE Q2W: 80 mg of ixekizumab every 2 weeks; IXE Q4W: 80 mg of ixekizumab every 4 weeks; LTE: long-term extension; MDA: minimal disease activity; PBO: placebo; Wk: week