Fig. 3.

Morris water maze relearning and probe trial for memory test after 12 weeks on the diet. a Latency to platform in the 4-day training phase. b Mean path length to reach the platform in the 4-day training phase. c Path efficiency to reach the platform during 4 days of training. d Time spent in the target quadrant during the probe trial (Pr3) following relearning expressed as percent of total distance in probe trial. e Swim speed in the Pr3. Animal numbers are as follows: control WT (n = 12), control TG (n = 11), HCD WT (n = 12), HCD TG (n = 11). Values are presented as mean ± SEM. Significance is indicated by ‡ between days 1 and 4 in control groups, by * between HCD TG and control WT. RM two-way ANOVA, one-way ANOVA, Tukey’s multiple comparisons test, p < 0.05. HCD hypercaloric diet, TG transgenic, WT wildtype