FIGURE 8.

Phylogenetic analysis of vancomycin-resistant Enterococcus faecium (VREfm) isolates from ST1421 Cluster 3B. The previously described recombination-filtered SNP threshold of ≤16 SNPs for VREfm has been used as a guide for identifying clonally related or non-unique isolates. (A) Overview of recombination-filtered SNPs between isolates. The numbers of different SNPs between the isolates are shown on the solid black connecting lines. SNP differences above the threshold of 16 SNPs are shown as blue dotted lines. (B) Spatio-temporal location of patients in Cluster 3B who tested positive for VREfm. The movement of patients following admission to hospital through to date of discharge are indicated with respect to time (x-axis) and hospital ward location (y-axis). Each line color represents an individual patient. As illustrated, a number of patients had multiple admissions to more than one hospital over the time course.