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A graphic model showing how copper ions may affect NGF signaling.
Copper released in the synaptic space binds to nerve growth factor (NGF) so to influence interaction with tropomyosin receptor kinase A (TrkA) and p75 receptors. Copper may influence metalloprotease (MMP) activity and then NGF release. NGF may influence copper transport inside cells (copper transporter protein 1 (Ctr1)) and then control metal homeostasis.
