Table 3.
The univariate and multivariate Cox proportional hazard regression analyses between the 5-gene signature and other clinical factors of NSCLC patients.
| Variables | Univariable analysis | Multivariable analysis | ||||||
|---|---|---|---|---|---|---|---|---|
| HR | Lower | Higher | P | HR | Lower | Higher | P | |
| 5-gene signature (high vs. low) | 3.93 | 2.17 | 7.1 | 0 | 5.18 | 2.6995 | 9.945 | <0.001 |
| Lymphovascular invasion (yes vs. no) | 1.37 | 0.58 | 3.26 | 0.476 | 1.03 | 0.4226 | 2.514 | 0.947 |
| Pleural invasion (yes vs. no) | 1.15 | 0.6 | 2.2 | 0.679 | 1.38 | 0.6977 | 2.745 | 0.352 |
| Chemotherapy (yes vs. no) | 1.1 | 0.59 | 2.05 | 0.76 | 0.94 | 0.4066 | 2.168 | 0.883 |
| Radiation (yes vs. no) | 1.26 | 0.56 | 2.84 | 0.579 | 1.42 | 0.4903 | 4.107 | 0.519 |