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. 2019 Dec 19;4(24):e122399. doi: 10.1172/jci.insight.122399

Figure 5. Ksp-β-cat–/– mice are protected from Adriamycin-induced kidney injury and proteinuria.

Figure 5

(A) Urine albumin excretion 3 weeks after injection of Adriamycin (22 mg/kg) in KSP-β-cat+/+ compared with KSP-β-cat–/– mice (*P < 0.05, t test). (B) Gel electrophoresis of urine samples showing reduction in albumin excretion in KSP-β-cat–/– mice. (C) Immunofluorescence showing greater nephrin disruption in KSP-β-cat–/– mice (original magnification, ×40). (D) Western blot demonstrating reduced kidney expression of MMP-7 in KSP-β-cat–/– mice. (E) Immunofluorescence for MMP-7 reveals strong upregulation in tubules from KSP-β-cat+/+ mice only (arrows denote positive staining; original magnification, ×20).